Microalgae and their metabolites are used in many fields such as agriculture, aquaculture, cosmetics, nutraceuticals and pharmaceuticals (Martínez-Ruiz et al. 2022). French Polynesia's large maritime area and the diversity of its ecosystems make it a strategic choice for research into molecules derived from marine organisms (i.e., marine natural products or MNPs). The development of high-throughput metabolite profiling and bioinformatic tools to process large datasets is now accelerating the discovery of new MNPs (Wolfender et al. 2019, Marcellin-Gros et al. 2020). The current challenge lies in the selection of relevant metabolites and their characterization in complex extracts. The CEVAMAP research program, launched in 2023, has studied the chemical diversity of a selection of 103 strains of French Polynesian microalgae (dinoflagellates, diatoms, cryptophyceae and cyanobacteria) using a metabolic profiling approach based on high-resolution mass spectrometry (LC-HRMS, Obitrap Exploris 120). The resulting dataset was processed using MzMine 3 and annotated through molecular networking (GNPS, cytoscape). Annotation coverage was then improved using SIRIUS 5.8.6 and Tima-r tools (Rutz et al. 2019) in addition to an in-house database obtained from purified compounds. More than 600 metabolites, most of them species-specific, were identified by comparison with databases, providing a map of the chemical diversity of the different microalgal species. In addition, two value-adding applications have also been identified for a selection of microalgae strains that have shown strong antiviral properties against the human syncital virus or larvicidal properties against Aedes egypti mosquitoes. Research into the molecules responsible for these activities is ongoing.